The indicate continual condition volume of distribution (Vss) for sildenafil is 105 L, indicating distribution in to the tissues. Sildenafil and its key circulating N-desmethyl metabolite are equally somewhere around 96% bound to plasma proteins. Protein binding is unbiased of complete drug concentrations.

This doc will not consist of all doable Unwanted side effects and Other folks may perhaps come about. Examine with all your physician For extra specifics of side effects.

Treatment need to be exercised by people who find themselves also taking protease inhibitors with the cure of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, successfully multiplying the plasma amounts of sildenafil, rising the incidence and severity of Uncomfortable side effects.

VIAGRA will not be indicated to be used in Females. There isn't any sufficient and very well-managed scientific studies of sildenafil in Expecting women.

Det er viktig at du ikke kombinerer denne potenspillen med andre legemidler uten at du har opplyst legen om at du bruker disse medisinene.

VIAGRA won't safeguard you or your partner from finding sexually transmitted illnesses, together with HIV—the virus that causes AIDS.

an erection that will not go away (priapism). In case you have an erection that lasts much more than four hrs, get health care support instantly. If It's not dealt with right away, priapism can permanently harm your penis.

There are actually postmarketing studies of bleeding events in sufferers who may have taken VIAGRA. A causal romance in between VIAGRA and these gatherings hasn't been recognized. In people, VIAGRA has no impact on bleeding time when taken on your own or with aspirin.

Physicians must explore with people the potential cardiac danger of sexual activity in patients with preexisting cardiovascular risk elements. Patients who encounter signs and symptoms (e.

Stronger CYP3A4 inhibitors like ketoconazole or itraconazole could possibly be anticipated to get better results than noticed with saquinavir. A beginning dose of twenty five mg of VIAGRA really should be viewed as in sufferers taking erythromycin or potent CYP3A4 inhibitors (for example saquinavir, ketoconazole, itraconazole) [see DOSAGE AND ADMINISTRATION, CLINICAL PHARMACOLOGY].

Blood pressure click here level was measured just after administration of VIAGRA at the identical periods as Those people specified for the earlier doxazosin scientific tests. There have been 3 subjects who experienced a standing SBP of < eighty five mmHg. All 3 had been taking VIAGRA a hundred mg, and all 3 noted mild adverse events at some time of reductions in standing SBP, which include vasodilation and lightheadedness. There were 4 subjects which has a lower from baseline in standing systolic BP > 30 mmHg pursuing VIAGRA 100 mg, a person matter with a lower from baseline in standing systolic BP > thirty mmHg subsequent placebo and just one subject which has a minimize from baseline in standing systolic BP > 30 mmHg adhering to both of those VIAGRA and placebo.

VIAGRA could be taken with or without food stuff. If you're taking VIAGRA after a high Excess fat meal (like a cheeseburger and french fries), VIAGRA may well acquire a bit for a longer period to get started on working

Suggest sildenafil plasma concentrations calculated after the administration of only one oral dose of 100 mg to wholesome male volunteers is depicted beneath:

Most studies assessed the efficacy of VIAGRA somewhere around sixty minutes publish dose. The erectile response, as assessed by RigiScan®, commonly elevated with rising sildenafil dose and plasma focus. Some time class of effect was examined in one study, showing an effect for up to four several hours although the reaction was diminished as compared to two hrs.